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This Biomedical Startup is Taking on Life-Threatening Fibrotic Disease
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There is a highly progressive and life threatening disease that affects approximately 130,000 people in the United States. Itβs worse than many cancers. According to the National Institute of Health, physicians are unsure of the cause, but the prognosis well-established; affected patients have a median life expectancy of about four years.
St. Louis-based bio-tech company Antegrin Therapeutics believes that that prognosis is unacceptable and is working to improve the lives of patients diagnosed with idiopathic pulmonary fibrosis (IPF).
IPF is characterized by scarring of the lungs causing an irreversible loss of the tissueβs ability to transport oxygen and ultimately resulting in the patientβs inability to breathe. There are currently very few FDA-approved medications to treat this debilitating disease which is often fatal without a lung transplant. George Capps, CEO of Antegrin Therapeutics, describes how Antegrin works to advance fibrosis treatment options.
βIntegrins are a family of proteins that promote fibrosisβAntegrin is developing drugs that inhibit integrins,βhe explains. βOur drugs are designed to slow the fibrotic process in IPF, as well as in other fibrotic diseases for which effective therapies are not available.β
Capps builds a compelling case for Antegrinβs ability to deliver viable treatment options. He cites his experienced team, strong intellectual property, powerful medicinal chemistry platform and compelling preclinical data, as the key drivers of the companyβs potential to transform the lives of patients living with IPF.
βWeβve demonstrated positive efficacy of our compound using inhaled delivery in a model of pulmonary fibrosis,β Capps says. βWe are very excited about this since inhaled delivery targets the drug to the organ, minimizing exposure, increasing our odds of excellent long-term safety.
In 2013Β the team published a paper in Nature Medicine demonstrating efficacy of an Antegrin compounds in models of lung and liver fibrosis.
βThe Nature Medicine publication was really a feather in our cap,βCapp says. βItβs one of the most prestigious medical journals.β The paper not only reports Antegrinβs initial preclinical data, but also details the scientific rationale for the companyβs approach. Since the publication of that paper, Capps notes that there has been βan unusually high level of incoming interest in Antegrin from big players in the industry.β
While there is a broad spectrum of fibrotic diseases, Capps is laser-focused on Antegrinβs go-to-market strategy.
βAs a small company, we concentrate on advancing our lead program, which is an inhaled therapy for IPF.β Still, he adds, βwe firmly believe that Antegrinβs platform technology presents the opportunity for tremendous value creation and multiple shots on goal.β Capps says the ultimate the goal for Antegrin is an exit by acquisition no later than the completion of a Phase 2 clinical trial in 2019 or 2020.
As the company strives toward its targeted exit date, sourcing investment funding is a constant concern for Capps. He explains, βBecause biology is so complicated, biopharmaceutical research is expensive and risky. Of course, the potential returns, should the technology succeed, are correspondingly high. But the large capital requirements and long timelines limit the pool of investors who are sophisticated enough to evaluate the investment opportunity.β
Capps is quick to point out that iSelect, a novel St. Louis based venture investment platform, has been instrumental in accessing accredited investors.
βWe launched on the iSelect platform last month. We experienced the intensive due-diligence process that they put their companies through. Itβs an arduous process, but iSelect seeks to minimize investorsβ risk by doing the diligence work most people donβt have the time or domain knowledge to sort out. I can testify that they do their homework!βΒ
iSelectβs investors recognize that investing in promising early-stage companies like Antegrin is a smart strategy when building a diversified portfolio. Antegrin is working with iSelect to raise $400,000 over the course of the next several months.
With B.S. and M.S. degrees in the Biological Sciences and an M.B.A. from Stanford University, Capps clarifies what life is like as the CEO of a bio-tech startup.
βPeople often think that startups are founded, people work 100 hours a week for six months, and then the company is sold for a billion dollars. Thatβs usually not what happens, and it is almost never the case in the biopharmaceutical space. Research can be slow and occasionally frustrating. But it is rewarding to work in an entrepreneurial environment with minimal bureaucracy and to be developing meaningful innovations with the potential to transform an peopleβs health and lifespan in a dramatic way.β